Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and insulin-modified FSIGT
                    
                        
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منابع مشابه
Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and insulin-modified FSIGT.
The minimal model is widely used to evaluate insulin action on glucose disappearance from frequently sampled intravenous glucose tolerance tests (FSIGT). The common protocols are a regular (rFSIGT, single injection of 0.3 g/kg of glucose) and an insulin-modified test (mFSIGT, with an additional insulin administration at 20 min). This study compared the insulin sensitivity index (SI) and glucose...
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A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 ( Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this...
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A Bayesian analysis of the minimal model was proposed where both glucose and insulin were analyzed simultaneously under the insulin-modified intravenous glucose tolerance test (IVGTT). The resulting model was implemented with a nonlinear mixed-effects modeling setup using ordinary differential equations (ODEs), which leads to precise estimation of population parameters by separating the interan...
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The intravenous glucose tolerance test (IVGTT) interpreted with the minimal model provides individual indexes of insulin sensitivity (S(I)) and glucose effectiveness (S(G)). In population studies, the traditional approach, the standard two-stage (STS) method, fails to account for uncertainty in individual estimates, resulting in an overestimation of between-subject variability. Furthermore, in ...
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Recent work in healthy subjects, the aged, and subjects with gestational diabetes or drug-induced insulin resistance using minimal model analysis of the tolbutamide-modified frequently sampled intravenous glucose tolerance test suggested that a reduced sampling regimen of 12 time points produced unbiased and generally acceptable estimates of insulin sensitivity (SI) and glucose effectiveness (S...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 1998
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.1998.274.4.e592